The gut virome of healthy children during the first year of life is diverse and dynamic

In this work, we determined the diversity and dynamics of gut virome infants during first year life. Fecal samples were collected monthly, from birth to one age, three healthy children living in a semi-rural village Mexico. Most viral reads classified into six families bacteriophages including five dsDNA virus order Caudovirales , with Siphoviridae Podoviridae being most abundant. Eukaryotic viruses detected as early two weeks after remained present all along Thirty-four different eukaryotic found, where eight these accounted for 98% reads: Anelloviridae Astroviridae Caliciviridae Genomoviridae Parvoviridae Picornaviridae Reoviridae plant-infecting Virgaviridae family. Some are known human pathogens, it is surprising that they found life without gastrointestinal symptoms. The species richness work was higher than observed previous studies; on average between 7 24 identified per sample. abundance significantly increased second semester life, probably because an environmental exposure age. Our findings suggest permanent contact diverse array viruses, whose composition changes over time. could represent metastable virome, potential influence development infant’s immune system or health later remains be investigated.